MUC1 CLIA Kit for Bovine(Bos taurus) | EIAab.comMUC1 CLIA Kit for Bovine(Bos taurus)

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MUC1 (Gene name),

Mucin-1 (Protein name ), MUC1_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MUC1;

Protein name:

Mucin-1(MUC-1);

Alternative:

CD:

CD227;

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

The alpha subunit forms a tight, non-covalent heterodimeric complex with the proteolytically-released beta subunit. Binds directly the SH2 domain of GRB2, and forms a MUC1/GRB2/SOS1 complex involved in RAS signaling. The cytoplasmic tail (MUC1CT) interacts with several proteins such as, SRC, CTNNB1 and ERBs. Interaction with the SH2 domain of CSK decreases interaction with GSK3B. Interacts with CTNNB1/beta-catenin and JUP/gamma-catenin and promotes cell adhesion. Interaction with JUP/gamma-catenin is induced by heregulin. Binds PRKCD, ERBB2, ERBB3 and ERBB4. Heregulin (HRG) stimulates the interaction with ERBB2 and, to a much lesser extent, the interaction with ERBB3 and ERBB4. Interacts with P53 in response to DNA damage. Interacts with KLF4. Interacts with estrogen receptor alpha/ESR1, through its DNA-binding domain, and stimulates its transcription activity. Binds ADAM17.

Function:

The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, Src and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates P53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of P53 and represses P53 activity.

Subcellular Location:

Mucin-1 subunit beta Cell membrane Cytoplasm Nucleus On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus.

Protein Attributes:

Sequence length:

580

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

580:

TKRSPYEEVS | AGNGGSNLSY | TNLAATSANL |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q8WML4

Pfam:

PF01390

UniGene:

Bt.9561

SMR:

Q8WML4

KEGG:

bta:281333

Uniprot:

Q8WML4

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ELISA Kit for Bovine MUC-1

Cat.:

E0413h

Price:

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Manual:

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Packing:

96T

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ELISA Kit for Bovine MUC-1

Cat.:

E0413m

Price:

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Bovine MUC-1

Cat.:

E0413b

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Bovine MUC-1

Cat.:

U0413b

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Bovine MUC-1

Cat.:

U0413m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

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CLIA Kit for Bovine MUC-1

Cat.:

U0413h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Bovine MUC-1

Cat.:

P0413Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Bovine MUC-1

Cat.:

P0413Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Bovine MUC-1

Protein for Bovine MUC-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Purification of MUC1 from bovine milk-fat globules and characterization of a corresponding full-length cDNA clone."
Pallesen L.T. , Andersen M.H. , Nielsen R.L. , Berglund L. , Rasmussen L.K. , Petersen T.E. , Rasmussen J.T.
J. Dairy Sci.84:2591-2598(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 23-35; 256-264; 276-282; 371-373; 387-397; 402-426 AND 523-528;GLYCOSYLATION;CARBOHYDRATE STRUCTURE
strain: Holstein.
tissue: Lactating mammary gland.
2.

"Molecular analysis of the length polymorphic MUC1 gene in cattle."
Rasero R. , Sacchi P. , Rosati S. , Cauvin E. , Maione S.
J. Anim. Breed. Genet.119:342-349(2002)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-554;POLYMORPHISM
strain: Friesian.
tissue: Blood.
3.

"Comparative FISH mapping of mucin 1, transmembrane (MUC1) among cattle, river buffalo, sheep and goat chromosomes: comparison between bovine chromosome 3 and human chromosome 1."
Perucatti A. , Floriot S. , Di Meo G.P. , Soglia D. , Rullo R. , Maione S. , Incarnato D. , Eggen A. , Sacchi P. , Rasero R. , Iannuzzi L.
Cytogenet. Genome Res.112:103-105(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-554
4.

"Distribution and carbohydrate structures of high molecular weight glycoproteins, MUC1 and MUCX, in bovine milk."
Liu C. , Erickson A.K. , Henning D.R.
J. Dairy Sci.88:4288-4294(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION

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